Recombinant Human CD161/CLEC5B-Fc Chimera (carrier-free)
Description
CLEC5B (CD161, KLRB1, NKR-P1A) is a C-type lectin protein belonging to the natural killer (NK) cell receptor family. Human CLEC5B is a 225 amino acid type II transmembrane glycoprotein. It contains a 158 amino acid extracellular domain with several motifs characteristic of C-type lectins, a 29 amino acid transmembrane domain, and a 38 amino acid cytoplasmic domain. CLEC5B plays an inhibitory role on NK cells by binding to CLEC2D/LLT1 and inhibiting NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. CLEC5B also reportedly acts as a potentiation receptor on T cells to increase IFN-gamma production in concert with TCR engagement. CLEC5B is known to be expressed by a distinct set of lymphocytes, in a subset of NK cells predominantly in intestinal epithelium and liver. It is also detected in peripheral blood T-cells, preferentially in adult T-cells with a memory antigenic phenotype.
Size
10 μg
Concentration
n/a
Applications
BA
Other Names
KLRB1, CD161, NKRP1A, NKR, Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, NKRP1A, NKR-P1