A potent, highly selective, and centrally active antagonist at the mGlu5a receptor subtype (IC50 = 36 nM); also has been reported as a positive allosteric modulator of mGluR4 at higher concentrations
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
96206-92-7 glutamates excitatory neurotransmitters antagonists metabotropic receptors mGluR anxiety depression mGlu5a mGluR4 non-competitives noncompetitives non competitives active subtypes mGlu5a mGlu-5a mGlu 5a anxiolytic-like anxiolytic allosterics modulators mGlu-R4 Hcl brains ionotropics transmissions epilepsy ischemia pains anxiety depressions cyclases 1 2 3 4 5 6 7 8 groups I II III adenylyl mGlu1b centrally actives in vivo rodents rats mouse mice positive