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Description
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al. , 2006 [PubMed 16805913]). [supplied by OMIM, Nov 2008]Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB. Subunit structure: Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 By similarity. Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1. Subcellular location: Cytoplasm > cytosol,NucleusSequence similarities: Contains 1 MYND-type zinc finger. Contains 1 SET domain.
Immunogen
Purified recombinant human KMT3C / SMYD2 protein fragments expressed in E.coli.