Recombinant Helicobacter pylori DNA protection during starvation protein (dps)
Description
Purity > 90% as determined by SDS-PAGE. MW: 32.9kDa. Full Length: 1-144aa. N-terminal 6xHis-SUMO-tagged. Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori). Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulation of neutrophils and monocytes at the site of infection. Induces superoxide anion generation, adhesion and chemotaxis of neutrophils, through a pertussis toxin-sensitive pathway involving MAP kinases.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Bacterioferritin; HP-NAP; Neutrophil-activating protein A; Short name:NAP A