ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) (N-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
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Description
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Defects in ATP2A1 are the cause of Brody myopathy (BRM). An autosomal recessive myopathy characterized by increasing impairment of relaxation of fast twist skeletal muscle during exercise.Subcellular location: Endoplasmic reticulum membrane, Multi-pass membrane protein. Sarcoplasmic reticulum membrane, Multi-pass membrane protein.Tissue specificity: Skeletal muscle, fast twitch muscle (type II) fibers. Also known as: AT2A1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase.
Immunogen
A synthetic peptide from the n-terminal region of human SERCA1 (Calcium pump 1) conjugated to an immunogenic carrier protein was used as the antigen.