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Description
Mouse Anti-TP53BP1 Recombinant Antibody (6B3E10). This product is a mouse monoclonal antibody that recognizes TP53BP1. The antibody 6B3E10 can be used for immunoassay techniques such as: ELISA, FC. This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. Diseases associated with TP53BP1 include Myeloproliferative
Immunogen
The immunogen corresponding to a region within amino acids 574 and 773 of human TP53BP1 expressed in E. Coli