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Description
A full length cDNA encoding mouse LGP2 was cloned by computational analysis, RTPCR, and RACE of liver and mammary tissue total RNA. Human LGP2 was also cloned. Yoneyama et al. have identified a DExD/Hbox-containing RNA helicase, retinoic acid inducible gene I (RIGI), as an essential component of the sensor of intracellular dsRNA. Furthermore, two other DexD/Hbox-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database. MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIGI/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses. Description: Serum. Synonyms: Polyclonal LGP2 antibody, Anti-LGP2 antibody, DEXH (Asp-Glu-X-His) box polypeptide 58 antibody, Probably ATP-dependent Helicase LGP2 antibody, D11LGP2 antibody, RLR antibody, TIG-I-Like Receptor LGP2 antibody, RNA Helicase LGP2 antibody, Ortholog of Mouse D11lgp2 antibody.
Immunogen
LGP2 antibody was raised in rabbit using a synthetic peptide corresponding to part of the cterminal of human LGP2 (IQAKKWSRVPFSV) as the immunogenSerum