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Description
ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. This ADAM17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the N-terminal region of human ADAM17.
Immunogen
Human ADAM17.
Other Names
A Disintegrin And Metalloprotease 17; ADAM17; CSVP; TACE; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD156b; MGC71942; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); cSVPADAM metallopeptidase domain 17; TNF-alpha converting enzyme; a disintegrin and metalloproteinas