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Description
Function: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.Tissue specificity: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: CASR, CaSR, Parathyroid cell calcium-sensing receptor, PCaR1, GPRC2A, PCAR1.
Immunogen
A synthetic peptide from the c-terminal region of human Extracellular calcium-sensing receptor (CaSR) conjugated to an immunogenic carrier protein was used as the antigen.