Suppressor of Cytokine Signaling 3 (SOCS3) (N-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB)
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Description
The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein 3 (CIS3/SOCS3/SSI3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BFER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPOdependent proliferation and STAT5 activation. It is reported that JAB/SOCS1 is strongly induced by interferongamma and forced expression of JAB/SOCS1 conferred cells interferon resistance. This resistance was caused by inhibition of JAK1 and JAK2 activation in response to IFN gamma. Moreover, recent detailed analysis of JAB/SOCS1 knockout mice revealed that JAB/SOCS1 is indeed a negative feedback regulator that determines the sensitivity of cells to IFN gamma. Description: Serum. Synonyms: Polyclonal SOCS antibody, Anti-SOCS3 antibody, CIS3 antibody, STAT-induced STAT inhibitor 3 antibody, Cytokine-inducible SH2 protein 3 antibody, ATOD4 antibody.
Immunogen
CIS3 antibody was raised in rabbit using a synthetic peptide corresponding to the Nterminal part of Human CIS3/SOCS3 as the immunogenSerum