Suppressor of Cytokine Signaling 3 (SOCS3) (pSer3)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse, rat, human
Isotype
n/a
Format
affinity purified
Size
50 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (IHC)
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Description
The suppressor of cytokine signaling (SOCS) family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway . The SOCS family consists of at least 8 members including the originally identified cytokine-inducible SH2-containing protein (CIS1), as well as SOCS1-7. Each SOCS family member contains a central SH2 domain and a conserved carboxy-terminal motif designated as the SOCS box. These proteins are important regulators of cytokine signaling, proliferation, differentiation, and immune responses. Low levels of SOCS3 are observed in lung, spleen and thymus, and like other SOCS family members levels its expression is rapidly induced by a number of factors including interleukins, EPO, IFN-gamma, CSF and TNF-alpha . SOCS3 uses its SH2 domain to bind activated Jaks and their cognate receptors to provide negative feedback inhibition. In addition to the initially described inducers of SOCS3 expression, subsequent studies have described SOCS3-mediated negative feedback inhibition for leptin , GH , chemokine receptors , insulin and certain pathogens . SOCS3 deletion results in embryonic lethality with placental insufficiency . SOCS3 signaling has been linked pathologically to allergic responses , inflammatory disease , endotoxic shock , wound repair , and obesity . Synonyms: SOCS3,ATOD4,CIS3,Cish3,MGC71791,SOCS-3,SSI-3,SSI3 ,