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Description
Rabbit polyclonal to RB1.Retinoblastoma-associated protein b) is a tumor suppressor and a key regulator of entry into celldivision. RB1 acts as a transcription repressor of E2F1 target genes. The hypophosphorylated, activeform of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest.RB1 is directly involved in heterochromatin formation by maintaining overall chromatin structure and,in particular, that of constitutive heterochromatin by stabilizing histone methylation. When it is time fora cell to enter S phase, complexes of cyclin-dependent kinases (CDK) and cyclins phosphorylate RB1and inhibit its activity.