Linker For Activation of T Cells Family, Member 2 (LAT2) (aa 30-203)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse, rat
Isotype
n/a
Format
Protein A purified
Size
0.1 mg
Concentration
n/a
Applications
Immunocytochemistry (ICC),Western Blotting (WB)
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Description
NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.