A dual modulator of p53-MDM2 interaction and NF-κB signaling; binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53; inhibits phosphorylation of IκBα and dose-dependently reduces nuclear accumulation of p65; inhibits cancer cell growth in vitro and in vivo
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical inhibitor cancer intracellular signaling gene regulation inflammation NF-κB dual modulator p53-MDM2 interaction bind mediated turnover inhibit phosphorylation IκBα reduce reduction nuclear accumulation p65 block proliferation cell line oral bioavailability bioavailable tumor growth A549 xenograft in vivo vitro