Flow Cytometry: 5 μg for 10^5 cells, Western Blot: Assay-dependent
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Description
CCR2 Monoclonal Antibody (48607.121). Chemokines have been sub-divided into families on the basis of the relative position of their cysteine residues. The alpha and beta families, with four cysteine residues, are the largest and best characterized. Chemokine receptors also activate small GTP-binding proteins of the Ras and Rho families, the latter being involved in cell motility events. In addition, chemokines bind to non-signaling molecules such as the Duffy antigen receptor for chemokines (DARC) which may act to remove chemokines from the circulation, and heparan sulfates proteoglycans which may serve to establish an ECM concentration gradient. CCR2A and CCR2B (MCP1RA and MCP1RB) differ in their alternatively spliced carboxy-terminus and