Plasminogen Activator Inhibitor 1, Recombinant, Human (PAI-1)
Description
Purified. ≥ 95% by SDS-PAGE. Recombinant PAI-1 comprises a 379 amino acid fragment (24-402) corresponding to the mature PAI-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag. PAI-1 is a serine protease inhibitor, which can exist either in an active inhibitory conformation or in an inactive or latent conformation. PAI-1 is produced mainly by the endothelium but is also secreted by other tissue types including adipose tissue. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, therefore inhibiting fibrinolysis. Increased levels of PAI-1 have been linked with various conditions including cardiovascular disease, thrombosis, insulin resistance and obesity. Applications: Suitable for use in ELISA.