Plasminogen Activator Inhibitor Type 1, Wild Type Latent, Rat (HEPES Buffer) (PAI-1)
Description
Purity ≥95% (SDS-PAGE). Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation. The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration. This binding has proven to be an important inhibitor of the activated form of protein C (APC). Concentration of Active PAI-1: Not detectable by SDS-PAGE Solubility: >2mg/ml and <5mg/ml