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Description
Rabbit IgG polyclonal Picoband? antibody for Phosphoglycerate kinase 1(PGK1) detection. Tested with WB in Human;Rat. No cross reactivity with other proteins. PGK1 (Phosphoglycerate Kinase 1), also known as PGKA, is an enzyme that in humans is encoded by the PGK1 gene. The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human PGK1 (312-337aa MGLDCGPESSKKYAEAVTRAKQIVWN), different from the related mouse and rat sequences by two amino acids.