The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.
Size
Various Sizes
Concentration
n/a
Applications
Cell Culture
Other Names
Interleukin-36 gamma;IL-1-related protein 2;IL-1RP2;Interleukin-1 epsilon;IL-1 epsilon;Interleukin-1 family member 9;IL-1F9;Interleukin-1 homolog 1;IL-1H1;IL36G;IL1E, IL1F9, IL1H1, IL1RP2;UNQ2456/PRO5737; IL-1F, IL-1ε (epsilon), IL-1H1