If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
The cAMP-dependent protein kinase (PKA) is a critical kinase involved in numerous biological functions. The PKA holoenzyme is composed of two regulatory and two catalytic subunits designated as PKA R and PKA C respectively. PKA R subunits exist as two classes, RI and RII, each containing two isoforms, alpha and beta. On the other hand, PKA C has three identified subunit isoforms, Calpha, Cbeta, and Cgamma, have been identified. The PKA R subunits allow a range of modifying agents to influence PKA activity and localization. They are found in different levels with tissue specificity. Following the bindings between PKA R subunits and the second messenger cAMP, active PKA C subunits are released, initiating a phosphorylation cascade that regulates many cellular functions such as metabolism, ion transport, and gene transcription.Rabbit Anti-PKA RIIalpha Polyclonal Antibody is developed in rabbit using a synthetic peptide (KLH-coupled) derived from human PKA regulatory IIalpha subunit (PKA RIIalpha).
Immunogen
Synthetic peptide (KLH-coupled) derived from human PKA regulatory IIα subunit (PKA RIIα)