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Description
BIRC7 protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Synonyms: Polyclonal BIRC7 antibody, Anti-BIRC7 antibody, baculoviral IAP repeat-containing 7, livin antibody, KIAP antibody, LIVIN antibody, ML-IAP antibody, MLIAP antibody, RNF50 antibody.
Immunogen
BIRC7 antibody was raised in rabbit using the middle region of BIRC7 as the immunogen