Recombinant Human Histone acetyltransferase KAT5 (KAT5), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 62.4kDa. Partial: 3-513aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the roval of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
60KDA Tat-interactive protein; Tip60Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5cPLA (2)-interacting protein