Recombinant Human Histone-binding protein RBBP7 (RBBP7)
Description
Purity > 90% as determined by SDS-PAGE. MW: 63.8kDa. Full Length: 1-425aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Core histone-binding subunit that may target chromatin rodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assbly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome rodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome rodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome rodeling factor) complex.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Histone acetyltransferase type B subunit 2Nucleosome-remodeling factor subunit RBAP46Retinoblastoma-binding protein 7; RBBP-7Retinoblastoma-binding protein p46