Recombinant Mouse Extracellular serine/threonine protein kinase FAM20C (Fam20c)
Description
Purity > 85% as determined by SDS-PAGE. MW: 60.4kDa. Full Length of Mature Protein: 88-579aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Mus musculus (Mouse). Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion