Long Insulin-like Growth Factor-I (Long-R3-IGF-I) (Arg3) (Active) protein
Description
Human Long Arg3 Insulin-like Growth Factor-I (Long R3 IGF-I) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Scientists have engineered this analog with the express purpose of increasing biological activity. Human Long-R3-IGF-I is significantly more potent than human IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of human Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs. Recombinant human Long Arg3 Insulin-like Growth Factor-I (Long R3 IGF-I), produced in E. coli, is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9,111 Da.Synonyms: Human Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) (Receptor Grade)