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Description
L3MBTL1 Monoclonal Antibody. L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternative
Immunogen
n/a
Other Names
H-L(3)MBT, L3MBTL, dJ138B7.3, l(3)mbt protein homolog, lethal (3) malignant brain tumor l(3), lethal(3)malignant brain tumor-like protein 1