ELISA. Anti-HDV has been tested in ELISA. Can be used as the tracer antibody in conjunction with Anti-Human Hepatitis D (MOUSE) Antibody (p/n 200-301-MB6) as the coating antibody. May be useful in additional assays. Specific conditions for reactivity should be optimized by the end user.
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Description
This purified monoclonal antibody is directed against hepatitis D and was purified by Ion exchange chromatography. Purity was confirmed by ELISA to be >95% pure. Hepatitis D (HDV) is one of the five hepatitis viruses of the liver. Hepatitis D Virus (hepatitis delta) is considered a subviral satellite because it can only propagate in the presence of hepatitis B virus. It can be transmitted as a coinfection simultaneously with HBV or as a superinfection. Both superinfection and coinfection with HDV results in more severe complications compared to infection with HBV alone. These complications include a greater likelihood of experiencing liver failure in acute infections and a rapid progression to liver cirrhosis, with an increased risk of developing liver cancer in chronic infections. In combination with hepatitis B virus, hepatitis D has the highest fatality rate of all the hepatitis infections, at 20%. With a genome of approximately 1700 nucleotides, HDV is the smallest virus known to infect animals. It has been proposed that HDV may have originated from a class of plant pathogens called viroids, which are much smaller than viruses. A significant difference between viroids and HDV is that, while viroids produce no proteins, HDV is known to produce one protein, namely HDAg. It comes in two forms; a 27kDa large-HDAg, and a small-HDAg of 24kDa. Anti-Human (HDV) Hepatitis D Antibody is useful for researchers interested in infectious disease.
Immunogen
Mouse monoclonal Anti-Human Hepatitis D [40.1.1.6] was produced in mice by repeated immunizations with Purified HDV strain virions.