Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA)
Description
Purity > 85% as determined by SDS-PAGE. MW: 39.4kDa. Full Length: 1-313aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Bos taurus (Bovine). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator