Recombinant Human Activin R1B/ALK-4-Fc-Chimera (carrier-free)
Description
The transforming growth factor- (TGF ) superfamily control a big number of biological responses and play a prominent role during embryonic development, regulation of cell growth, differentiation, and apoptosis. 40 distinct TGF members have been identified in vertebrates and they are generally divided into two branches, the TGF /activin/nodals and the bone morphogenetic proteins (BMPs). Activin A is a morphogen during embryonal development, regulating chondrogenic and osteogenic differentiation of mesenchymal progenitor cells (MPC).? Activin A binds two type I and two type II serine/threonine kinase receptors. The type I receptors are named activin receptor-like kinases 1 to 7 (ALK1~7) and Activins bind to ALK4 and ALK7.The type II receptor kinase is constitutively active and phosphorylates the type I receptor after the formation of the ligand-receptor complex.? Five type II receptors have been identified: ActRIIA, ActRIIB, BMPRII, TGFβRII, and MISRII. Activin A binds to ALK-4 and ActRIIB. Activin Recptor 1B (ALK-4) interacts with different ligands. The complex myostatin/activin type I receptor (ALK4) is a mediator of muscle atrophy and muscle regeneration. In addition, cripto binds to cell surface ALK4 expressed on mammalian epithelial cells, and activates nodal- and ALK4-dependent and -independent signaling pathways.
Size
500 μg
Concentration
n/a
Applications
BA
Other Names
Activin Receptor-Like Kinase 4(ALK4), Serine/Threonine-Protein Kinase Receptor R2 (SKR2), Activin A Receptor, Type IB (ACTRIB), ACVRLK4, Activin Receptor Type IB.