An adenosine A2B receptor antagonist (Ki = 0.553 nM); selective for adenosine A2B over A1, A2A, and A3 receptors (Kis = >10,000 nM); reduces intracellular calcium concentrations in Jurkat T cells expressing the human A2B receptor (IC50 = 1.13 nM); reduces Zika viral plaque formation (IC50 = 43.8 nM); delays tumor growth and reduces tumor volume and the number of pulmonary metastases in the B16 mouse model of melanoma at 0.25 μg/head, i.p.,