WM3758 is a metastatic human melanoma cell line. This cell line contains a Q61L mutation at position 61 in the N-RAS gene. The Q61L mutation results in an amino acid substitution at position 61 in NRAS, from a glutamine (Q) to a leucine (L). This cell line expresses wild type BRAF, c-KIT, and CDK4 genes. WM3758 cells match with WM3682 and WM3702. These cells produce xenograft tumors when injected into immunocompromised mice.
Size
1 mL
Concentration
1.0 million cells/ml
Applications
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Other Names
Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft