Purified (~70-90%). NIK is a mitogen-activated protein kinase kinase kinase 14 (MAP3K14), which binds to TRAF2 and stimulates NF-kappaB activity. NIK shares sequence similarity with several other MAPKK kinases and participates in NF-kappaB-inducing signalling cascade common to receptors of the tumor-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. NIK is expressed in primary human cells and in inflamed rheumatoid arthritis tissue and plays a selective role in signaling by the lymphotoxin-beta receptor. NIK is a therapeutic target in the immune and bone-destructive components of inflammatory arthritis. Source: Recombinant protein corresponding to human NIK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~108kD Specific Activity: 8nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL)