WM3406 is a human metastatic melanoma cell line that displays a mesenchymal morphology. This cell line contains a Q61K mutation at position 61 in the N-RAS gene which causes increased signaling via the extracellular signal-regulated MAPK/ERK kinase pathways to enhance proliferation. This cell line also expresses mutated PTEN gene and is wild type for BRAF, c-KIT and CDK4. WM3406 cells produce xenograft tumors when injected into immunocompromised mice.
Size
1 mL
Concentration
1x10^6
Applications
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Other Names
Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft