A methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM); inhibits the ERG1, ERG2, and ERG3 isoforms with KD values of 99, 116, and 193 nM, respectively
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
113558-89-7 voltage-gated voltage gated potassiums ERGs channels Kv11.1 Kvs Kv-11.1 11.1 ether-a-go-go ether a go related genes hERG IKr K+ methanesulfonanilide class III antiarrhythmic anti-arrhythmic anti arrhythmic agents cardiac actions potential duration ADP channel blockers blocks blocking 1 2 3 one two three ERG-1 ERG-2 ERG-3 ERG1 ERG2 ERG3 torsade de long QT sydromes types 2 LQT2 cardiac diseases intervals E4031 E 4031 HCl ions pumps inhibitors inhibits inhibitions cardiology cardio