Early Growth Response 2 (EGR2) (aa 153-168), (N-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human, mouse
Isotype
n/a
Format
immunogen affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB)
Reviews / Ratings
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Description
Early growth response protein 2, also called EGR2 or E3 SUMO-protein ligase EGR2, is a protein that in humans is encoded by the EGR2 gene. This gene is mapped to 10q21.3. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D(CMT1D), Charcot-Marie-Tooth disease type 4E(CMT4E), and with Dejerine-Sottas syndrome(DSS). E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human EGR2(153-168aa TMSQTQPDLDHLYSPP), different from the related rat and mouse sequences by one amino acid.