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Description
BTK/BPK(Tyr551) Polyclonal Antibody. ? Target Background: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphoryl
Immunogen
KLH conjugated synthetic phosphopeptide derived from human Btk around the phosphorylation site of Tyr551 [DE(p-Y)TS]