DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) drug conjugate
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Description
Anti-cKIT (NEG087)-SMCC-DM1 ADC. This Antibody-Drug Conjugate (ADC) product is comprised of an anti-cKIT monoclonal antibody (NEG087) conjugated via a SMCC linker to DM1. The DM1 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM1 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.