Product Specifications Rat IGFBP-5: Description: Rat Insulin-like Growth Factor Binding Protein-5 (rIGFBP-5) is a 252 amino acid protein that is one of the six ' A``classical' IGF binding proteins that play an important role in stabilizing and regulating the activity of IGFs in vivo. Rat IGFBP-5 preferentially binds IGF-II and it also binds with high affinity to extracellular matrix components which protect it from proteolysis. Like human IGFBP-5, rat IGFBP-5 has a nuclear targeting sequence.
Kiefer M. et al. (1991) Biochem. Biophys. Res. Commun. 176, 219-225 Song, H. et al. (2000) J. Mol Endocrinol. 24, 43-51 Source: Produced recombinantly in E.coli. Purified by affinity and other chromatographic steps. Purity: > 90% (by SDS PAGE) Molecular Weight: 29 kDa (non-glycosylated; five amino acid N-terminal extension) Biological Activity: Binds IGF-I in western ligand blot. Binding affinity for IGF-I - 0.2nM (Biosensor). State and Appearance: Lyophilized white powder dried from phosphate buffered saline and stored under dry nitrogen at a slight vacuum (-25 kPa) Storage/Stability: At least 2 years at 2 - 4°C (lyophilized) This a Novozymes GroPep Specification! ibt is authorized distributor of GroPep!