An antagonist of ERα that blocks 17β-estradiol-induced proliferation of drug-resistant cancer cell lines at concentrations ranging from 10 to 1,000 nM; drives tumor regression in mice bearing MCF-7 xenografts; inhibits ERα-dependent protein synthesis by activating the unfolded protein response in cells
Size
500 μg
Concentration
n/a
Applications
n/a
Other Names
3,3-bis (p-hydroxyphenyl)-7-methyl-2-indolinone steroid receptor antagonist endocrinology nuclear gene regulation cancer biochemical ERα ERa estrogen α a ER