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Description
PFK2 (Ser467) Polyclonal Antibody, Alexa Fluor? 647 Conjugated. ? Target Background: 6 Phosphofructo 2 Kinase plays a role in the synthesis and degradation of fructose 2,6-bisphosphate. Fructose-2,6-bisphosphate acts as an allosteric regulator of 6-phosphofructo-1-kinase (PFK1), which catalyses a key step in the glycoytic pathway. Glycolytic flux is key to tumour growth, and small molecule inhibition of 6 Phosphofructo 2 Kinase suppresses both glycolytic flux and tumour growth. Several lines of evidence suggest that 6 Phosphofructo 2 Kinase is also involved in obesity.
Immunogen
KLH conjugated synthetic phosphopeptide derived from human PFK2 around the phosphorylation site of Ser467. Immunogen Range: 458-520/520