A STAT3 inhibitor (IC50 = 4.7 μM for STAT3 homodimer DNA binding activity); selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5; decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells; inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively); inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models at 3 mg/kg per day
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
SH454 STAT 1 3 5 MB231 U251 MG SH4 54 SH 454 NIH 3T3 Bcl2 MDAMB231