p53, mutant, Recombinant, Human (Tumor Suppressor Protein, Oncogene Protein)
Description
Purity ≥ 90% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. Recombinant Mutant p53 shows a band at 81kD on SDS-PAGE commassie blue stained gel. Dimers and Aggregates: ≤ 1% as determined by coomassie blue SDS-PAGE gel analysis. Endotoxin: ≤ 0.1ng/ug (IEU/ug) of Human Mutant p53.