Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (aa 20-764), (Extracellular)
Clone
4B4
Host Species
Mouse
Reactive Species
human
Isotype
IgG1
Format
ascites
Size
0.1 mL
Concentration
n/a
Applications
Western Blotting (WB),Immunofluorescence (IF),Flow Cytometry (FACS),ELISA
Reviews / Ratings
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Description
KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas.Synonyms: FLK1, CD309, VEGFR, VEGFR2
Immunogen
Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.