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Description
c-Cbl Monoclonal Antibody (3B12). The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Immunogen
n/a
Other Names
C-CBL, CBL2, NSLL, RNF55, E3 ubiquitin-protein ligase CBL; RING finger protein 55; casitas B-lineage lymphoma proto-oncogene; oncogene CBL2; proto-oncogene c-Cbl; signal transduction protein CBL