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| Antigenic Specificity | c-Cbl |
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| Clone | S.551.7 |
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| Host Species | Rabbit |
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| Reactive Species | human, nonhuman primate |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 1:50, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | c-Cbl Monoclonal Antibody (S.551.7). The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. |
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| Immunogen | n/a |
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| Other Names | E3 ubiquitin-protein ligase CBL; RING finger protein 55; casitas B-lineage lymphoma proto-oncogene; oncogene CBL2; proto-oncogene c-Cbl; signal transduction protein CBL |
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| Gene, Accession # | Entrez: 867; Uniprot: P22681 |
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| Catalog # | MA5-14955 |
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| Price | |
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| Order / More Info | c-Cbl Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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