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Description
NT-3 is a member of the structurally related neurotrophin family of proteins, which includes beta-NGF, BDNF and NT-4. NT-3 is expressed in a number of cell types including neuronal cells, eosinophils, and melanocytes. NT-3 is required for the development of peripheral sensory neurons. NT-3 is secreted from cells as a precursor protein, which is proteolytically cleaved into the mature form. NT-3 signaling is mediated through two distinct receptors, the neurotrophin receptor p75NTR and the Trk tyrosine kinase receptor TrkC. While all neurotrophins bind to the p75NTR receptor, NT-3 preferentially binds to TrkC and, with lesser affinity, TrkB.Synonyms: NTF3, HDNF, MGC129711, NGF-2, NGF2, NT3