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Description
NT-4 is a member of the structurally related neurotrophin family of proteins, which includes beta-NGF, BDNF and NT-3. NT-4 is expressed in a number of cell types and tissues, including neuronal cells, normal breast epithelial cells, melanocytes, activated T cells, and granulocytes. NT-4 is required for the development of peripheral sensory neurons. NT-4 may be important for the development of long term memory. Increased NT-4 expression in melanoma cells promotes cell proliferation and migration. NT-4 is secreted from cells as a precursor protein, which is proteolytically cleaved into the mature form. NT-4 signaling is mediated through two distinct receptors, the neurotrophin receptor p75NTR and the Trk tyrosine kinase receptor TrkB. While all neurotrophins bind to the p75NTR receptor, NT-4 preferentially binds to the TrkB receptor.Synonyms: NTF4, NT-4/5, NT4, NT5, NTF5