An inhibitor of MMP-2 and MMP-9 (IC50s = 10-20 μM, for both); selective for MMP-2 and MMP-9 over MT1-MMP, MMP-8, and MMP-13 as well as the serine proteases trypsin-2, neutrophil elastase, and cathepsin G (500 μM); reduces migration of HT1080 fibrosarcoma, C8161 melanoma, SK-OV-3 ovarian carcinoma, and KS1767 Kaposi's sarcoma cells in vitro; pretreatment delays tumor formation in an MDA-MB-435 mouse xenograft model; prevents growth of established tumors in MDA-MB-435 and KS1767 mouse xenograft models,
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III