bovine, Drosophila, human, mouse, nonhuman primate, rat, zebrafish
Isotype
n/a
Format
purified
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 1:25, Western Blot: 1:1000
Reviews / Ratings
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Description
N-cadherin Polyclonal Antibody. N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracel