Recombinant Human DNA (cytosine-5)-methyltransferase 3A (DNMT3A), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 29.9kDa. Partial: 680-902aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA